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EC number: 203-742-5
CAS number: 110-16-7
The spermicidal effect of maleic acid was
evaluated by adding the acid to the sperm, and by observing sperm
survival and penetration following addition to human cervical mucus.
A concentration of 0.1 % maleic acid reduced
the pH from 7.5 to 5.5 and rendered human spermatozoa immotile within 30
min, and 1 % (pH 1.5) was almost instantaneously spermicidal. In
capillaries filled with cervical mucus, the incorporation of 0.01 %
maleic acid was sufficient to reduce sperm penetration, and at 0.1 %
penetration was completely prevented.
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