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EC number: 203-742-5
CAS number: 110-16-7
According to the one-compartment model, 99% of steady state was reached
by day 55 of the study. The dogs were maintained at steady state for the
final 35 days of the 90 day study.
In a 90 day feeding study with Beagle dogs (7 days a week, ad libitum),
no adverse effects were reported at all dose groups.
An uptake rate constant of 0.00349 per day and an elimination rate
constant of 0.0832 per day were calculated assuming an one-compartment
Highest dose tested: NOEL = 60 mg/kg/day.
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