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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicology of the eye
Author:
Grant J (ed)
Year:
1986
Bibliographic source:
In: Toxicology of the eye, 3rd ed., 574. Springfield, IL: Charles C. Thomas
Reference Type:
review article or handbook
Title:
Final report on the Safety Assessment of Maleic Acid
Author:
American College of Toxicology
Year:
2007
Bibliographic source:
International Journal of Toxicology 26, 125-130

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit

Test system

Amount / concentration applied:
10 % to 1 %
Duration of treatment / exposure:
30 sec (10 %) to 2 min (1 %)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: permanent corneal opacity and vascularization
Basis:
other: no data
Remarks on result:
other: test substance concentration 10 %, pH 1.0
Irritation parameter:
other: transient corneal cloudiness
Basis:
other: no data
Remarks on result:
other: test substance concentration 1 %, pH 1.0

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In the eyes of rabbits, maleic acid caused permanent corneal opacity and vascularization at a concentration of 10% (pH= 1.0) after 30 seconds, and transient corneal cloudiness at a concentration of 1 % (pH = 1.0) after 2 minutes.