Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
See also SIDS Initial Assessment.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Concentrations:
0.72 mg/L
No. of animals per sex per dose:
6 rats in total

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.72 mg/L air
Mortality:
No mortality occurred.
Clinical signs:
Generalized inactivity, hyperpnea, sedation within 15 minutes of exposure
Gross pathology:
No significant findings

Applicant's summary and conclusion

Conclusions:
The LC50 was >0.72 mg/L air for rats exposed to the maleic acid for 1 hour.