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EC number: 203-742-5
CAS number: 110-16-7
Wollny (2010), in vitro gene mutation test: Negative
Lake (1988), Ames test: Negative
Ishidate (1980), Ames test (maleic anhydride): Negative
Ishidate (1980), in vitro chromosome aberration test (maleic anhydride):
Ishidate (1988), in vitro chromosome aberration test (maleic anhydride):
Positive without metabolic activation
Yanasigawa (1987), inhibition of DNA synthesis: DNA synthesis was
One Ames test and one in vitro gene mutation
assay with maleic acid were negative and DNA
sythesis was inhibited in another study.
One Ames test with maleic anhydride also
gave negative results. One in vitro chromosome aberration study with
maleic anhydride was performed only without a metabolising system and
gave positive results, one other in vitro chromosome aberration study
with maleic anhydride gave ambiguos results. In the SIDS report on
maleic acid and maleic anhydride it is stated that "maleic
anhydride is known to hydrolyze to maleic acid in aqueous media. Due
to inadequate documentation on this study, it is unclear whether the
results were due to the test material itself or a change in pH to an
acidic environment, which could have resulted in a non-specific effect."
Overall, it is concluded that maleic acid
does not have significant mutagenic potential.
No classification is derived from the
results of the mutagenicity tests.
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