Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-742-5
CAS number: 110-16-7
The skin sensitization potential of Maleic Acid was assessed in a human
repeat insult patch study. A total of 105 subjects participated in the
study. Subjects were exposed to 9 induction patches containing 0.5 ml of
0.3 % v/v Maleic Acid in distilled water under occlusion on a Monday,
Wednesday and Friday schedule for a period of 3 weeks. Patches were
removed 24 hours after each application and patch sites were graded at
48 hours after patch application prior to the next patch application.
After a two week rest period subjects were challenged with 0.5 ml of 0.3
% v/v Maleic Acid in distilled water (24 hour patch exposure). Challenge
patch sites were graded at 48 and 96 hours after patch application.
In this study, 101/105 subjects completed the study. A total of four (4)
subjects discontinued participation because of reasons listed below:
Unable to attend due to illness not skin related
Unable to attend due to employment circumstances
No positive responses indicative of skin sensitization was observed.
Maleic Acid did not produce skin sensitization in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Damit Sie die Website optimal nutzen können, verwenden wir Cookies.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again