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EC number: 203-742-5
CAS number: 110-16-7
Maleic anhydride was mixed with the
food and administered on 7 day/week ad lib., for 90 consecutive days to
four Beagle dogs/sex/dose. Doses were 0, 20, 40 or 60 mg/kg body weight.
Body weights and food consumption were
recorded, and the dogs were observed for signs of toxicity. Clinical
parameters were evaluated by determination made prior to the beginning
of the study and at intervals throughout the test period. These included
hematological studies, urinalysis and various clinical chemistry
studies. Gross examination was conducted at necropsy after the exposure
period, organ weights were examined, and tissues were obtained for
intake was decreased for the first few weeks in both sexes of dogs
receiving 60 mg/kg/day. Hematological
studies conducted after 83 days of exposure indicated equivocal
decreases in packed cell volume and hemoglobin concentration of male
dogs receiving 60 mg/kg/day. No
other changes were observed that were considered relatable to the
ingestion of diets containing maleic anhydride.
NOEL was defined to be 60 mg/kg/day for both sexes of Beagle dogs.
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