Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-742-5
CAS number: 110-16-7
Maleic anhydride was mixed with the
food and administered on 7 day/week ad lib., for 90 consecutive days to
four Beagle dogs/sex/dose. Doses were 0, 20, 40 or 60 mg/kg body weight.
Body weights and food consumption were
recorded, and the dogs were observed for signs of toxicity. Clinical
parameters were evaluated by determination made prior to the beginning
of the study and at intervals throughout the test period. These included
hematological studies, urinalysis and various clinical chemistry
studies. Gross examination was conducted at necropsy after the exposure
period, organ weights were examined, and tissues were obtained for
intake was decreased for the first few weeks in both sexes of dogs
receiving 60 mg/kg/day. Hematological
studies conducted after 83 days of exposure indicated equivocal
decreases in packed cell volume and hemoglobin concentration of male
dogs receiving 60 mg/kg/day. No
other changes were observed that were considered relatable to the
ingestion of diets containing maleic anhydride.
NOEL was defined to be 60 mg/kg/day for both sexes of Beagle dogs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again