Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 55 mg/kg bw/day
Additional information
No adverse effects on litter size and on pup survival were observed at doses up to 150 mg/kg/day in the F1 litters, or at 55 mg/kg/day in the F2 litters. Microscopic examination of tissues from pups in the F2 liters revealed no treatment-related changes. Therefore, treatment up to 55 mg/kg/day for two generations had no adverse effect on pups.
Short description of key information:
IRDC, 1982: Three Generation Reproduction Study in Rats (Modified to a Two Generation Study) with the closely related substance maleic anhydride: no adverse effects on fertility up to 55 mg/kg/day. Since maleic anhydride will convert to maleic acid very quickly in a solution, it is assumed this result (NOAEL) is also applicable for maleic acid.
Justification for classification or non-classification
Additional information
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