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EC number: 203-742-5
CAS number: 110-16-7
Acute oral toxicity, rat:Eastman 1969: LD50 = 708 mg per kg body weightLöser 1978 (maleic anhydride): LD50 = 1030 mg/kg body weightMürmann 1984 (maleic anhydride): LD50 = 1090 mg/kg body weightAcute dermal toxicity, rabbit:Vernot 1977 (maleic anhydride): LD50 = 2620 mg/kg body weightSax 1989: LD50 = 1560 mg/kg body weightYounger Labs 1976 (maleic anhydride): 298 <LD50<1000 mg/kg body weightAcute toxicity, inhalation:Existing data are inadequate to determine the acute toxicity by inhalation.
Acute oral toxicity:
LD50 data for maleic acid as well as for maleic
anhydride are in the same range: 708, 1030, 1090 mg per kg body weight
and result in the same classification. Therefore the data for maleic
acid are used for classification (LD50 = 708 mg/kg bw). These data are
also flagged "critical study for SIDS endpoint" in the SIDS dossier.
Acute dermal toxicity:
LD50 data for maleic acid are 1560 mg per kg body
weight, whereas the LD50 data for maleic anhydride are between
(practically) 400 and 100 mg/kg or above 2000 mg/kg (2620 mg/kg). For
safety reasons, the data on maleic acid are taken for classification
(1560 mg/kg bw). These data are also flagged "critical study for SIDS
endpoint in the SIDS dossier.
Acute inhalation toxicity: Inhalation
is not relevant, as the size particles are to large to inhale.
The derivation of the relevant toxicity descriptors and the calculation
of the DNELs and their justifications was the task of DSM Netherlands.
DSM Netherlands requested to use their data and justifications in the
Based on the LD50 of 708 mg per kg body
weight for oral toxicity the test substance is classified as "R22
Harmful if swallowed" and as "Acutely toxic Category 4".
Based on the LD50 of 1560 mg per kg body
weight for dermal toxicity the test substance is classified as "R21
Harmful in contact with skin" and as "Acutely toxic Category 4".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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