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EC number: 203-742-5
CAS number: 110-16-7
This report describes the ability of Maleic acid to pass through a
bio-barrier and to elicit a colour change in the underlying liquid
chemical detection system. The study procedures described in this report
were based on the most recent OECD guideline OECD 435. Maleic acid was a
white solid with a purity of 100.1%. The test substance compatibility
test showed that Maleic acid was compatible with the chemical detection
system. Based on the acid reserve, Maleic acid was classified as a
timescale 1 compound. Maleic acid was applied directly (approximately
500 mg) on top of the bio-barrier matrix. The elapsed time between
application and penetration was determined by monitoring changes in the
chemical detection system. The penetration time of Maleic acid was 25
minutes. Since Maleic acid was a timescale 1 test substance and showed a
mean penetration time of 25 minutes, based on this test Maleic acid
would be classified as Skin Corrosive 1B (CLP) and UN packing group II
(= GHS 1B). The negative control citric acid (10%) showed a mean
penetration time of >60 minutes (actual penetration time 95 minutes) and
was therefore non-corrosive. The positive control sodium hydroxide (as
it is) showed a mean penetration time of 22 minutes and was therefore
classified as UN packing group II (=GSH 1B). It was therefore concluded
that the test system functioned properly. Finally, it is concluded that
this test is valid and that Maleic acid would be classified as Skin
Corrosive 1B (CLP) and UN packing group II (= GHS 1B) in the Corrositex®
assay under the experimental conditions described in this report.
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