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EC number: 445-790-1
CAS number: 404362-22-7
In a Klimisch-1 -rated OECD 421 Reproduction / Developmental Toxicity
Screening Study no teratogenic effects were being observed up to the
highest dose level tested of 40 mg/kg bw/d (NOEL).
The NOAEL for systemic toxicity in liver has to be based on the gross
lesions that were recorded only in a few high dose animals. A
correlating increase in glycogen contents was noted in these few males
and females although the body weights were decreased in high dose
animals. Therefore, a relation to an effect of the test item cannot be
excluded definitely at 40 mg/kg bw/day and the NOAEL was established at
15 mg/kg bw/day based on the livers with gross lesions.
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