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EC number: 445-790-1
CAS number: 404362-22-7
Absorption: assumed oraly and dermaly well absorbed; inhalation negligibleDistribution: no informationMetabolism: no informationExcretion: no information
No ADME and dermal
absorption study with the Gaskamine 240 are available.
However, three oral
toxicity studies give an indication about the bioavailability after oral
application. In an acute toxicity study, one 28 days repeated dose
toxicity study and one reproductive/developmental toxicity screening
study systemic toxicity was observed after oral Gaskamine 240 exposure
leading to the conclusion that the test substance is bioavailable after
application in a mice sensitization study (local lymph node assay) the
substance provoke skin sensitization suggesting sufficient dermal
absorption. The octanol/water partition coefficient is determined with >
6.2 (30°C) indicates high lipophilic property of the substance and the
mean molecular weight is with 292.4 g/mol rather low. Therefore, a good
dermal absorption rate of Gaskamine 240 can be assumed.
Gaskamine 240 is a
viscous liquid at room temperature and vaporization is deemed negligible
as the vapour pressure is
1.3 x 10-5 Pa (25 C°). Therefore, inhalation exposure is only
possible via aerosols of dissolved material.
Gaskamine 240 is
hydrolytically stable in neutral, acidic and alkaline solutions at room
temperature. Therefore it can be assumed that no hydrolysis takes place
during the rather fast stomach passage and the unchanged substance
reaches the small intestine where it might be absorbed. No chemical
hydrolysis can be expected in the blood and intracellular. Due to the
low water solubility and the high partition coefficient of Gaskamine 240
accumulation in fatty tissues is likely after entering the body.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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