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EC number: 445-790-1
CAS number: 404362-22-7
In an acute oral toxicity test, the LD50 was in the range between 500 and 2000 mg/kg. As the submission item turned out to be corrosive, no further acute testing was performed.
An acute oral toxicity test of the reaction product of 1,1'-(benzene-1,3
-diyl)bis(methylamine) and styrene was conducted in compliance with the
OECD Test Guidelines No. 401 (1987) in the rat.
The reaction product was orally administered by gavage to SD rats (SPF).
The tested concentrations lay in the range of 25 to 2000 mg/kg bw and 6
male and 6 female rats were treated per concentration. No abnormalities
were detected in animals treated with 200 mg/kg bw or less. Animals
treated with 500 mg/kg bw showed clinical signs (body descent, abnormal
gait (male), squatting (female), diarrhea, loss of fur), but no
abnormalities were observed on Day 3 or later. All animals treated with
2000 mg/kg bw died within 5 hours after application.
The LD50 of the test material was determined to be in the range of 500
and 2000 mg/kg. Accordingly, the reaction product falls into acute
toxicity hazard category 4 according to Regulation (EC) No 1272/2008
An acute oral toxicity test was conducted in compliance with OECD TG No.
401. The submission item was orally administered by gavage to male and
female rats. The acute oral LD50 of the test material was in the range
between 500 and 2000 mg/kg bw.
As the submission item turned out to be corrosive, neither the dermal
nor the inhalative route of application was tested in an acute toxicity
test in accordance with Regulation (EC) 1907/2006, column 2 of Annex
The acute oral LD50 was determined to be in the range of 500 and 2000
mg/kg in an acute oral toxicity test.
Regulation (EC) No 1272/2008 (CLP): Acute oral toxicity hazard category
4, H302 "Harmful if swallowed".
Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC): Xn; R22
"Harmful if swallowed".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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