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EC number: 445-790-1
CAS number: 404362-22-7
The substance exhibited long-term adverse effects on Daphnia magna in a 21-day chronic aquatic toxicity test performed under semi-static conditions. The NOEC based on reproduction was 0.14 mg/L.
The long-term toxicity of the submission item to aquatic invertebrates (Daphnia
magna) was studied in a GLP long-term aquatic toxicity test in
accordance with OECD TG 211 under semi-static conditions for a period of
21 days. The definitive test was performed using test concentrations of
0.014, 0.044, 0.14, 0.44 and 1.4 mg/L. The test material was dissolved
in dimethylformamide and solvent stock solutions were then prepared,
before the test solutions were adjusted by dilution in specially
prepared culture medium. A control and a solvent control were run in
parallel. Analytical confirmation of the nominal concentrations was
carried out by measuring the test substance concentrations by means of
HPLC. Especially the low measured concentrations were highly variable,
but good agreement between nominal and measured concentrations was seen
around the LOEC and the time-weighted mean measured concentrations
(calculated from duplicate measured concentrations found in freshly
prepared and expired test media) were in the range of 84 to 114% for the
0.14, 0.44 and 1.4 mg/L dose groups. The conditions of the test were
such that reproduction was by parthenogenesis. Animals were taken from
in-house laboratory cultures by separating young daphnids produced
overnight. 10 healthy females each were distributed randomly over the
testing vessels and controls.
Long-term exposure of aquatic invertebrates (Daphnia magna) to
the test substance Gaskamine 240 resulted in significant mortalities at
the test concentrations of 0.44 mg/L (60% after 21 days) and 1.4 mg/L
(100% after 4 days). In addition, the reproductivity was significantly
decreased in animals exposed to 0.44 mg/L. No effects (mortality,
reproduction) were seen at lower test concentrations and the NOEC was
0.14 mg/L after 21 days of exposure.
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