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EC number: 445-790-1
CAS number: 404362-22-7
A reliable study on the ready biodegradability of the submission item (a
modified MITI test in accordance with OECD TG 301-C, Iizuka 2002) showed
that no biodegradation of the substance was observed over the test
period of 28 days. Considering the lack of biodegradation observed in
the ready biodegradation test, it is to be expected that the submission
item is unlikely to be degraded to a significant extent under the
conditions of an inherent biodegradability study, unless a toxic effect
to the microorganism community was the reason for the absence of
degradation. In the study of Clarke (2002) on the toxicity to
microorganisms according to OECD TG 209 the NOEC was found to be 10
times lower than the initial concentration in the ready biodegradation
test of 100 mg/L. The EC 50 in this study was at 70 % of the
concentration used in the MITI test for ready biodegradability. It seems
therefore possible, that significant intoxication of the microorganism
community prevented biodegradation the MITI test.
Nonetheless, as long as no data are becoming available indication
ultimate biodegradability of the substance under real environmental
conditions, the test item should be regarded as non-biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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