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EC number: 445-790-1
CAS number: 404362-22-7
An acute oral toxicity test of the reaction product of 1,1'-(benzene-1,3
-diyl)bis(methylamine) and styrene was conducted in compliance with the
OECD Test Guidelines No. 401 (1987) in the rat.
The reaction product was orally administered by gavage to SD rats (SPF).
The tested concentrations lay in the range of 25 to 2000 mg/kg bw and 6
male and 6 female rats were treated per concentration. No abnormalities
were detected in animals treated with 200 mg/kg bw or less. Animals
treated with 500 mg/kg bw showed clinical signs (body descent, abnormal
gait (male), squatting (female), diarrhea, loss of fur), but no
abnormalities were observed on Day 3 or later. All animals treated with
2000 mg/kg bw died within 5 hours after application.
The LD50 of the test material was determined to be in the range of 500
and 2000 mg/kg. Accordingly, the reaction product falls into acute
toxicity hazard category 4 according to Regulation (EC) No 1272/2008
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