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EC number: 445-790-1
CAS number: 404362-22-7
Primary dermal irritation study was performed with MXDA/SM Adduct in
accordance with OECD guideline No. 404 (1981).
The test substancewas applied to three different sites topically dermal
(approximately 6 cm2) on the back of the one New Zealand White rabbit
for 3 minutes (one patch), 1 hour (second patch) and 4 hours (third
patch) of exposure. After completion of the exposure period the treated
areas were observed after 1h, 24 h, 48 h and 72 h post exposure.
Moderate to severe erythema (Score 3 -4) and odema (Score 3-4) were
noted at all three application sites after 24 until 72 h post exposure.
At time point 24 h and 48 h after removal of patches green and brown
colouration of each site appeared. These zones were surrounded with an
erythemateous zone. At time point 72h the additinally skin suppleness
decreased and necrosis was noted.
Based on the result above, the test material was decided to be a
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