3,5,5-trimethylhexan-1-ol

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

Secondary source. Original report not yet available

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1971

Reference 2

Reference Type:

other: review

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Principles of method if other than guideline:

Determination of dermal flux of 1-nonanol in human skin (epidermis) in vitro

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Nonan-1-ol

EC Number:

205-583-7

EC Name:

Nonan-1-ol

Cas Number:

143-08-8

Molecular formula:

C9H20O

IUPAC Name:

Nonan-1-ol

Test animals

Species:

human

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Results and discussion

Percutaneous absorption

Remarks on result:

other:

Any other information on results incl. tables

Skin absorption is low; the dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm²/h.

Applicant's summary and conclusion

Conclusions:

Skin absorptin of 3,5,5-trimethylhexan-1-ol is considered to be low, i.e. comparable to the isomeric 1-nonanol, whose dermal flux of 1-nonanol in human skin (epidermis) in vitro was 0.003 mg/cm²/h.

Executive summary:

Skin absorption of 1-nonanol is low. The dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm²/h (Schueplein, 1971). Based on comparable physico-chemical properties it is assumed that the skin absorption of the isomer 3, 5, 5 -trimethylhexan-1-ol is comparable and, therefore, low.