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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Remarks:
Secondary source. Original report not yet available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1971
Reference Type:
other: review
Title:
Unnamed
Year:
2005
Report Date:
2005

Materials and methods

Principles of method if other than guideline:
Determination of dermal flux of 1-nonanol in human skin (epidermis) in vitro
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Percutaneous absorption
Remarks on result:
other:

Any other information on results incl. tables

Skin absorption is low; the dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm2/h.

Applicant's summary and conclusion

Conclusions:
Skin absorptin of 3,5,5-trimethylhexan-1-ol is considered to be low, i.e. comparable to the isomeric 1-nonanol, whose dermal flux of 1-nonanol in human skin (epidermis) in vitro was 0.003 mg/cm²/h.
Executive summary:

Skin absorption of 1-nonanol is low. The dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm2/h (Schueplein, 1971). Based on comparable physico-chemical properties it is assumed that the skin absorption of the isomer 3, 5, 5 -trimethylhexan-1-ol is comparable and, therefore, low.