Registration Dossier
Registration Dossier
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EC number: 222-376-7 | CAS number: 3452-97-9
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature (Patty's Toxicology and Industrial Hygiene, 2005)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,5,5-trimethylhexan-1-ol
- EC Number:
- 222-376-7
- EC Name:
- 3,5,5-trimethylhexan-1-ol
- Cas Number:
- 3452-97-9
- Molecular formula:
- C9H20O
- IUPAC Name:
- 3,5,5-trimethylhexan-1-ol
- Details on test material:
- a nonyl alcohol rich in trimethylhexanol
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Duration of treatment / exposure:
- 50 treatment during 75 days
- Frequency of treatment:
- 5/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.6 to 2.0 mL/kg bw/day
Basis:
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- < 1 800 mg/kg bw/day (nominal)
- Basis for effect level:
- other: growth retardation
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Applicant's summary and conclusion
- Conclusions:
- Not assignable.
- Executive summary:
Contact of 5 mL (1.6 to 2.0 g/kg) of nonyl alcohol for 1 h/day with the skin of rabbits on each of 50 days over a period of 75 days resulted in retarded growth and erythema but no mortality. However, this is only based on personal communication and there is no written information existent which would confirm this finding, hence the reliability is low (RL=4) (Fassett, 1963).
On the other hand, skin absorption of 1-nonanol is low; the dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm2/h (Scheuplein, 1971). The lack of overt dermal toxicity of n-nonanol is therefore plausible.
The same should apply to the isomeric 3, 5, 5,-trimethylhexan-1 -ol, as the physico-chemical properties are comparable.
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