Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature (Patty's Toxicology and Industrial Hygiene, 2005)
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1963
Report Date:
1963

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
a nonyl alcohol rich in trimethylhexanol

Test animals

Species:
rabbit

Administration / exposure

Duration of treatment / exposure:
50 treatment during 75 days
Frequency of treatment:
5/week
Doses / concentrations
Remarks:
Doses / Concentrations:
1.6 to 2.0 mL/kg bw/day
Basis:

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
< 1 800 mg/kg bw/day (nominal)
Basis for effect level:
other: growth retardation

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Contact of 5 mL (1.6 to 2.0 g/kg) of nonyl alcohol for 1 h/day with the skin of rabbits on each of 50 days over a period of 75 days resulted in retarded growth and erythema but no mortality.

Applicant's summary and conclusion

Conclusions:
Not assignable.
Executive summary:

Contact of 5 mL (1.6 to 2.0 g/kg) of nonyl alcohol for 1 h/day with the skin of rabbits on each of 50 days over a period of 75 days resulted in retarded growth and erythema but no mortality. However, this is only based on personal communication and there is no written information existent which would confirm this finding, hence the reliability is low (RL=4) (Fassett, 1963).

On the other hand, skin absorption of 1-nonanol is low; the dermal flux of 1-nonanol in human skin (epidermis) in vitro is 0.003 mg/cm2/h (Scheuplein, 1971). The lack of overt dermal toxicity of n-nonanol is therefore plausible. 

 

The same should apply to the isomeric 3, 5, 5,-trimethylhexan-1 -ol, as the physico-chemical properties are comparable.