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EC number: 222-376-7 | CAS number: 3452-97-9
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Database of the Japanese National Institute of Technology and Evaluation. Information on the chemical published in the Official Bulletin of Economy,Trade and Industry (Former title:The Official Bulletin of the Ministry of International Trade and Industry (published before Jan.6, 2001)). Original reference received in 2012: GLP guideline study.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- yes
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 30 mg/L
- Duration of test (contact time):
- 4 wk
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- gas chromatography
- Details on study design:
- TEST CONDITIONS
- Test temperature: 25°C
TEST SYSTEM
- Volume of test solution: 300 mL
SAMPLING
- Other: no data
CONTROL AND BLANK SYSTEM
- Other: no data
STATISTICAL METHODS: calculation of means of 3 replicate experiments - Parameter:
- other: BOD
- Value:
- 3.67
- St. dev.:
- 1.15
- Sampling time:
- 4 wk
- Parameter:
- % degradation (TOC removal)
- Value:
- 4
- St. dev.:
- 4
- Sampling time:
- 4 wk
- Details on results:
- BOD and TOC data represent means +/- SD of 3 determinations
- Parameter:
- BOD5
- Value:
- ca. 3.67 other: %
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Biodegradation of 3,5,5 -trimethylhexan-1-ol was approx. 4% within 4 days, i.e. the test substance was not readily biodegradable
- Executive summary:
- 3,5,5 -trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C). Biodegradation was <4% BOD after 28 days of incubation. It was demonstrated that approx. 55% of the test substance was oxidised to 3,5,5,-trimethylhexanoic acid which was not further degraded within the 28 days of incubation (CERI 2007; NITE; 2002).
Reference
|
Results percentage biodegradation(%) |
average |
||
BOD |
5 |
3 |
3 |
4 |
TOC |
0 |
4 |
8 |
4 |
GC |
56 |
49 |
59 |
55 |
Description of key information
3,5,5-trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
3,5,5 -trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C). Biodegradation was <4% BOD after 28 days of incubation. It was demonstrated that approx. 55% of the test substance was oxidised to 3,5,5,-trimethylhexanoic acid which was not further degraded within the 28 days of incubation (CERI 2007; NITE; 2002).
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