3,5,5-trimethylhexan-1-ol

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Database of the Japanese National Institute of Technology and Evaluation. Information on the chemical published in the Official Bulletin of Economy,Trade and Industry (Former title:The Official Bulletin of the Ministry of International Trade and Industry (published before Jan.6, 2001)). Original reference received in 2012: GLP guideline study.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))

GLP compliance:

yes

Inoculum or test system:

activated sludge (adaptation not specified)

Details on inoculum:

- Concentration of sludge: 30 mg/L

Duration of test (contact time):

4 wk

Initial conc.:

100 mg/L

Based on:

test mat.

Parameter followed for biodegradation estimation:

O2 consumption

Parameter followed for biodegradation estimation:

TOC removal

Parameter followed for biodegradation estimation:

test mat. analysis

Remarks:

gas chromatography

Details on study design:

TEST CONDITIONS
- Test temperature: 25°C


TEST SYSTEM
- Volume of test solution: 300 mL


SAMPLING
- Other: no data


CONTROL AND BLANK SYSTEM
- Other: no data



STATISTICAL METHODS: calculation of means of 3 replicate experiments

Parameter:

other: BOD

Value:

3.67

St. dev.:

1.15

Sampling time:

4 wk

Parameter:

% degradation (TOC removal)

Value:

4

St. dev.:

4

Sampling time:

4 wk

Details on results:

BOD and TOC data represent means +/- SD of 3 determinations

Parameter:

BOD5

Value:

ca. 3.67 other: %

	Results percentage biodegradation(%)			average
BOD	5	3	3	4
TOC	0	4	8	4
GC	56	49	59	55

 

Validity criteria fulfilled:

yes

Interpretation of results:

under test conditions no biodegradation observed

Conclusions:

Biodegradation of 3,5,5 -trimethylhexan-1-ol was approx. 4% within 4 days, i.e. the test substance was not readily biodegradable

Executive summary:

3,5,5 -trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C). Biodegradation was <4% BOD after 28 days of incubation. It was demonstrated that approx. 55% of the test substance was oxidised to 3,5,5,-trimethylhexanoic acid which was not further degraded within the 28 days of incubation (CERI 2007; NITE; 2002).

Description of key information

3,5,5-trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C)

Key value for chemical safety assessment

Biodegradation in water:

under test conditions no biodegradation observed

Additional information

3,5,5 -trimethylhexan-1-ol was not readily biodegradable in the MITI-I test (i.e. OECD 301C). Biodegradation was <4% BOD after 28 days of incubation. It was demonstrated that approx. 55% of the test substance was oxidised to 3,5,5,-trimethylhexanoic acid which was not further degraded within the 28 days of incubation (CERI 2007; NITE; 2002).