3,5,5-trimethylhexan-1-ol

Ecotoxicological Summary

Conclusion on classification

(1) The proposed classification (Environment) according to 67/548/EC would be as follows:

(a) Basis for classification:

Acute toxicity to fish: LC50 (96 h)= 27.7 mg/L, based on measured concentrations (CITI, 1997).     R52

Acute toxicity to Daphnia: EC50 (48 h) = 6.77 mg/L (CITI, 1997).                                                        R51

Acute toxicity to algae: EbC50 (0 -72 h) = 19.5 mg/L (measured concentration)                                   R52

Biodegradation: not readily biodegradable                                                                                           

log Pow: 3.42, i.e ≥ 3.0 (but BCF 3.9 -8.1, i.e. ≤ 100; therefore not R53!))

(b) Classification (67/548/EC, No. 5.2.1.1)

N, R51 Toxic to aquatic organisms.

(c) Classification (1272/2008/EC, No. 4.1)

Aquatox chronic 2; H411

(2) Examination, whether PBT or vPvB apply

criterion	result	justification	reference
PBT
persistence	+ / -	inadequate data
bioaccumulation	No	BCF 2000	NITE (2002; RL 2)
Toxic (a)           Long term aquatic NOECs (b)           CMR (c)           T (or Xn), R48 according to 67/548 EC	No No + / -	(a1) fish: NOEC >0.01 mg/L (a2) aqu. invertebrates: NOEC >0.01 mg/L C: no data M: negative R: negative inadequate data: (1)    Japanese language; (2)   Short-term study: pregnant females (3)   no subchronic study available.	CITI (1997; RL4) CITI (1997; RL4) No data MHLW (1997, RL2) MHLW (1997, RL2) MHLW (1997, RL2)
Overall result PBT: No
vPvB
persistence	+ / -	inadequate data
bioaccumulation	No	BCF 5000	NITE (2002; RL 2)
Overall result vPvB	No