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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5,5-trimethylhexan-1-ol
EC Number:
222-376-7
EC Name:
3,5,5-trimethylhexan-1-ol
Cas Number:
3452-97-9
Molecular formula:
C9H20O
IUPAC Name:
3,5,5-trimethylhexan-1-ol
Details on test material:
no detail information

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
No eye wash
Observation period (in vivo):
10 days
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing: no
- Time after start of exposure:


SCORING SYSTEM: Draize method; readings at approx. 1, 24, 48, and 72 hours, and on days 7 an d10


TOOL USED TO ASSESS SCORE: no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
mean score of 3 animals
Time point:
24/48/72 h
Score:
0.2
Max. score:
0.7
Reversibility:
fully reversible within: 7 days
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
mean score of 3 animals
Time point:
24/48/72 h
Score:
0.3
Max. score:
0.3
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
mean score of 3 animals
Time point:
24/48/72 h
Score:
0.8
Max. score:
1
Reversibility:
fully reversible within: 7 days

Any other information on results incl. tables

Effect

Mean scores (3 animals)

1 h

24 h

48 h

72 h

7d

10 d

Corneal opacity

0

0

0

0.7

0

0

Conjunctival chemosis

1.0

0.3

0.3

0.3

0

0

Conjunctival redness

1.0

1.0

0.7

0.7

0

0

Applicant's summary and conclusion

Conclusions:
3,5,5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye below the level of the EU criteria for labelling
Executive summary:

3, 5, 5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye when it was tested according to OECD TG 405 under GLP in 3 rabbits. The maximum Draize score reached was 18 out of 110. The corneal and conjunctival effects were all fully reversible within 7 days.

In conclusion, 3, 5, 5-trimethylhexan-1-ol was only slightly irritating to the rabbit's eye below the level of the EU criteria for labelling (EBSI, 2002).