Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Eye Contact: Immediately flush eyes with water; remove contact lenses, if present, after the first 5 minutes, then continue flushing eyes for at least 15 minutes. Obtain medical attention without delay, preferably from an ophthalmologist.

Skin Contact: Immediately wash skin with soap and plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Obtain medical attention without delay. Wash clothing before reuse. Destroy contaminated articles such as shoes.

Inhalation: Move person to fresh air. If not breathing, give artificial respiration; if by mouth to mouth use rescuer protection (pocket mask, etc). If breathing is difficult, oxygen should be administered by qualified personnel. Call a physician or transport to a medical facility.

Ingestion: Do not induce vomiting. Call a physician and/or transport to emergency facility immediately. Seek medical attention immediately.

Notes to Physician: Because rapid absorption may occur through the lungs if aspirated and cause systemic effects, the decision of whether to induce vomiting or not should be made by a physician. If lavage is performed, suggest endotracheal and/or esophageal control. Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach. Respiratory symptoms, including pulmonary edema, may be delayed. Persons receiving significant exposure should be observed 24-48 hours for signs of respiratory distress. Maintain adequate ventilation and oxygenation of the patient. If burn is present, treat as any thermal burn, after decontamination. No specific antidote. Treatment of exposure should be directed at the control of symptoms and the clinical condition of the patient.

Medical Conditions Aggravated by Exposure: Excessive exposure may aggravate preexisting lung, liver, and kidney disease.

Emergency Personnel Protection: First Aid responders should pay attention to self-protection and use the recommended protective clothing (chemical resistant gloves, splash protection).

Fire-fighting measures

Extinguishing Media: Water fog or fine spray. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers. Foam. Do not use direct water stream. Straight or direct water streams may not be effective to extinguish fire. Alcohol resistant foams (ATC type) are preferred. General purpose synthetic foams (including AFFF) or protein foams may function, but will be less effective. Water fog, applied gently may be used as a blanket for fire extinguishment.

Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Stay upwind. Keep out of low areas where gases (fumes) can accumulate. Water may not be effective in extinguishing fire. Use water spray to cool fire exposed containers and fire affected zone until fire is out and danger of reignition has passed. Fight fire from protected location or safe distance. Consider the use of unmanned hose holders or monitor nozzles. Do not use direct water stream. May spread fire. Eliminate ignition sources. Move container from fire area if this is possible without hazard. Burning liquids may be moved by flushing with water to protect personnel and minimize property damage. Water fog, applied gently may be used as a blanket for fire extinguishment.

Special Protective Equipment for Firefighters: Wear positive-pressure self-contained breathing apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers, boots, and gloves). Avoid contact with this material during fire fighting operations. If contact is likely, change to full chemical resistant fire fighting clothing with self-contained breathing apparatus. If this is not available, wear full chemical resistant clothing with self-contained breathing apparatus and fight fire from a remote location. For protective equipment in post-fire or non-fire clean-up situations, refer to the relevant sections.

Unusual Fire and Explosion Hazards: Container may rupture from polymerization. Violent steam generation or eruption may occur upon application of direct water stream to hot liquids. Vapors are heavier than air and may travel a long distance and accumulate in low lying areas. Ignition and/or flash back may occur. Flammable mixtures may exist within the vapor space of containers at room temperature. Flammable concentrations of vapor can accumulate at temperatures above flash point.

Hazardous Combustion Products: During a fire, smoke may contain the original material in addition to combustion products of varying composition which may be toxic and/or irritating. Combustion products may include and are not limited to: Hydrogen chloride. Carbon monoxide. Carbon dioxide.

Accidental release measures

Steps to be Taken if Material is Released or Spilled:
Ground and bond all containers and handling equipment. Pump with explosion-proof equipment. If available, use foam to smother or suppress. Contained liquids should be recovered free of separate water phase, preferrably by use of air-operated or other non-spark producing pump. Do not touch or walk through spilled material. Final cleanup can be similar to small spills. For smaller spills, and if the contaminated water can be properly disposed, deluge or flood the spill area with sufficient water to remove the product. Epichlorohydrin will slowly hydrolyze to less volatile and less flammable (but still toxic) compounds when dissolved in water. Use Soda Ash (Na2CO3) in conjunction with the water to react with the epichlorohydrin and convert it to glycerine. Be sure to prevent a two-phase mixture, thus avoiding potential reactivity hazards. If contaminated water can not be disposed of properly, small spills can be collected using a solid absorbent product. Contain spilled material if possible. Do NOT use absorbent materials such as: Clay. Milsorb®. DRIERITE. ABSORB-N-DRI. Cellulose. Absorb with materials such as: Polyethylene fiber products. Polypropylene fiber products. Sand. Perlite. Spills on bare ground may necessitate the removal of contaminated earth. The moisture in the soil can react with this product in a hazardous manner. Therefore, careful monitoring of removed soil and prompt disposal is advantageous.

Personal Precautions: For large spills, warn public of downwind explosion hazard. Eliminate all sources of ignition in vicinity of spill or released vapor to avoid fire or explosion. Vapor explosion hazard. Keep out of sewers. Check area with combustible gas detector before reentering area. Ground and bond all containers and handling equipment. Use appropriate safety equipment. Keep unnecessary and unprotected personnel from entering the area. Isolate area. Eliminate all sources of ignition in vicinity of spill or released vapor to avoid fire or explosion. Ground and bond all containers and handling equipment. Only trained and properly protected personnel must be involved in clean-up operations. Evacuate area. Keep upwind of spill. Ventilate area of leak or spill. No smoking in area. Keep personnel out of low areas.

Environmental Precautions: Prevent from entering into soil, ditches, sewers, waterways and/or groundwater.

Handling and storage

Handling
General Handling: Keep away from heat, sparks and flame. Do not breathe vapor. Avoid contact with eyes, skin, and clothing. Do not swallow. Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. Electrically bond and ground all containers, personnel and equipment before transfer or use of material. Use of non-sparking or explosion-proof equipment may be necessary, depending upon the type of operation. No smoking, open flames or sources of ignition in handling and storage area.

Other Precautions: Vapors are heavier than air and may travel a long distance and accumulate in low lying areas. Ignition and/or flash back may occur. Never use air pressure for transferring product. Containers, even those that have been emptied, can contain vapors. Do not cut, drill, grind, weld, or perform similar operations on or near empty containers. Spills of these organic materials on hot fibrous insulations may lead to lowering of the autoignition temperatures possibly resulting in spontaneous combustion.

Storage
Minimize sources of ignition, such as static build-up, heat, spark or flame. Do not store product contaminated with water to prevent potential hazardous reaction. Keep containers tightly closed when not in use to prevent formation of carbonate salts. Keep container tightly closed. Store in the following material(s): Carbon steel. Stainless steel. Avoid contact with: Do not store in: Zinc. Bronze. Aluminum. Aluminum alloys. Copper alloys. Brass. Copper. Magnesium. Magnesium alloys. Do not store mixtures of this product and water to avoid potential for hazardous reaction. Maintain a nitrogen atmosphere. Keep container tightly closed when not in use. Store away from incompatible materials. Storage tanks should be blanketed with nitrogen and the oxygen concentration should be maintained below eight (8%) percent.

Transport information

Land transport (ADR/RID)

UN number:
ID Number: UN2023
Kemler Code: 63
Tremcard Number: 61S2023
Proper shipping name and description:
Proper Shipping Name: EPICHLOROHYDRIN
Chemical name:
1-chloro-2,3-epoxypropane
Language:
English
Class:
Hazard Class: 6.1 (3)
Classification code:
Classification: TF1
Packaging group:
Packing Group: PG II
Labels:
T-Toxic
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
ID Number: UN2023
Shippingopen allclose all
Class:
Hazard Class: 6.1 (3)
Classification code:
Classification: TF1
Packaging group:
Packing Group: PG II
Labels:
T-Toxic
Remarksopen allclose all

Marine transport (IMDG)

UN number:
ID Number: UN2023
Proper shipping name and description:
Proper Shipping Name: EPICHLOROHYDRIN
Chemical name:
1-chloro-2,3-epoxypropane
Class:
Hazard Class: 6.1 (3)
Packaging group:
Packing Group: PG II
EmS code:
EMS Number: F-E,S-D
Labels:
T-Toxic
Marine pollutant
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
ID Number: UN2023
Proper shipping name and description:
Proper Shipping Name: EPICHLOROHYDRIN
Chemical name:
1-chloro-2,3-epoxypropane
Class:
Hazard Class: 6.1 (3)
Packaging group:
Packing Group: PG II
Labels:
T-Toxic
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Personal Protection
Eye/Face Protection: Use chemical goggles. Chemical goggles should be consistent with EN 166 or equivalent. If exposure causes eye discomfort, use a full-face respirator.
Skin Protection: Use protective clothing chemically resistant to this material. Selection of specific items such as face shield, boots, apron, or full body suit will depend on the task. Safety shower should be located in immediate work area. Remove contaminated clothing immediately, wash skin area with soap and water, and launder clothing before reuse or dispose of properly. Items which cannot be decontaminated, such as shoes, belts and watchbands, should be removed and disposed of properly.
Hand protection: Use chemical resistant gloves classified under Standard EN374: Protective gloves against chemicals and micro-organisms. Examples of preferred glove barrier materials include: Butyl rubber. Polyethylene. Chlorinated polyethylene. Styrene/butadiene rubber. Polyvinyl alcohol ("PVA"). Ethyl vinyl alcohol laminate ("EVAL"). Examples of acceptable glove barrier materials include: Viton. Neoprene. Natural rubber ("latex"). Polyvinyl chloride ("PVC" or "vinyl"). Nitrile/butadiene rubber ("nitrile" or "NBR"). When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than 240 minutes according to EN 374) is recommended. When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according to EN 374) is recommended. NOTICE: The selection of a specific glove for a particular application and duration of use in a workplace should also take into account all relevant workplace factors such as, but not limited to: Other chemicals which may be handled, physical requirements (cut/puncture protection, dexterity, thermal protection), potential body reactions to glove materials, as well as the instructions/specifications provided by the glove supplier.
Respiratory Protection: Atmospheric levels should be maintained below the exposure guideline. When respiratory protection is required, use an approved self-contained breathing apparatus or positive pressure air line with auxiliary self-contained air supply. For emergency and other conditions where the exposure guideline may be exceeded, use an approved positive-pressure self-contained breathing apparatus or positive-pressure air line with auxiliary self-contained air supply. In confined or poorly ventilated areas, use an approved self-contained breathing apparatus or positive pressure air line with auxiliary self-contained air supply.
Ingestion: Avoid ingestion of even very small amounts; do not consume or store food or tobacco in the work area; wash hands and face before smoking or eating.

Engineering Controls
Ventilation: Provide general and/or local exhaust ventilation to control airborne levels below the exposure guidelines. Lethal concentrations may exist in areas with poor ventilation.

Stability and reactivity

Stability/Instability
Stable under recommended storage conditions.
Conditions to Avoid: Exposure to elevated temperatures can cause product to decompose. Avoid two phase storage with water, a slow exothermic reaction may be initiated. Avoid open flames, welding arcs, or other high temperature sources which induce thermal decomposition.

Incompatible Materials: Avoid contact with oxidizing materials such as: Sodium hypochlorite. Chlorine. Avoid contact with: Amines. Acids. Bases. Avoid contact with absorbent materials such as: Cellulose-based absorbents. Clay-based absorbents.

Hazardous Polymerization
Can occur. Elevated temperatures can cause hazardous polymerization. Polymerization can be catalyzed by: Zinc. Aluminum. Amines. Copper. Lead. Strong acids. Strong bases.

Thermal Decomposition
Decomposition products depend upon temperature, air supply and the presence of other materials.

Disposal considerations

This product, when being disposed of in its unused and uncontaminated state should be treated as a hazardous waste according to EC Directive 91/689/EEC. Any disposal practices must be in compliance with all national and provincial laws and any municipal or local by-laws governing hazardous waste. For used, contaminated and residual materials additional evaluations may be required. Do not dump into any sewers, on the ground, or into any body of water.