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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The 96-hour LC50 value of 10.6 mg/L for epichlorohydrin is taken from a valid exposure study with fathead minnows (Pimephales promelas).

Key value for chemical safety assessment

LC50 for freshwater fish:
10.6 mg/L

Additional information

Two acute freshwater fish studies and one acute saltwater fish study were assessed for this endpoint. One study was conducted with fathead minnows (Pimephales promelas), one study was conducted with bluegill sunfish (Lepomis macrochirus) and one study was conducted with tidewater silversides (Menidia beryllina). All three studies were determined to be of good quality and acceptable for use in risk assessment. The study conducted with fathead minnows tested the sensitivity of fish at different life-stages to epichlorohydrin, and concluded that there was no real difference in sensitivity to epichlorohydrin based on age of the exposed fish. The LC50 values for fathead minnow fry, juveniles, and subadults were 12.7, 10.6 and 13.2 mg/L epichlorohydrin, respectively. The acute test with epichlorohydrin and bluegill sunfish reported a 96-hour LC50 of 35 mg/L. The acute test with epichlorhydrin and tidewater silversides (a saltwater species) reported a 96-hour LC50 of 18 mg/L. The lowest 96-hour LC50 value of 10.6 mg/L for fathead minnows was selected as the key parameter for this endpoint.