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EC number: 203-439-8 | CAS number: 106-89-8
Pregnant rats exposed to ECH at 25 pprn had significantly decreased body weights and food consumption during gestation as compared to controls. No evidence of altered appearance or demeanor was observed among exposed rats. Liver weights (absolute and relative) were comparable to controls for rats exposed to ECH. Reproductive parameters including number of pregnant females, number of corpora lutea, number of implantations, litter size and incidence of resorbing fetuses were not adversely affected in rats exposed to ECH. Fetal body weights and measurements in rats were not affected by exposure to ECH. Low incidences of malformations were observed among rat fetuses from both the exposed and the control groups. Single occurrences of acaudia, rotated limb or paw, encephalomeningocele, shortened ventricles of the brain and missing ribs or vertebrae were observed in the 25 ppm group. At 2.5 pprn, single occurrences of shortened trunk, rotated limb or paw, external hydrocephalus, a misshapen occipital bone and missing vertebrae were observed. These malformations have been observed to occur sporadically among control litters of Sprague-Dawley rats in this laboratory. Several malformed fetuses were also observed among the concurrent control fetuses. In some cases 2 or more of the malformations occurred in the same fetus. When considered collectively, the total number of fetuses which had one or more major malformations was less in each of the 2 exposed groups (3 in 3 litters), than in controls where 5 fetuses in 4 litters were malformed.
Pregnant Sprague-Dawley rats were exposed to vapors of epichlorohydrin (ECH) at concentrations of 0, 2.5 or 25 pprn. Exposures were for 7 hr/day on days 6 through 15 (rats) of gestation. Maternal effects including decreased body weight and food consumption were observed among rats inhaling 25 pprn of ECH. No evidence of an adverse effect to the embryo or fetus was observed among rats following exposure to ECH. Thus, ECH was not teratogenic or embryolethal in rats following inhalation exposure to concentrations which induced effects in the maternal animals.
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