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EC number: 203-439-8 | CAS number: 106-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Remarks:
- Not specified in report
- GLP compliance:
- yes
- Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- Breakdown products are not discussed in the report. However, it is known that hydrolysis of epichlorohydrin results in the formation of 3-Chloro-1,2-propanediol also known as alpha-monochlorohydrin.
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 7.3 d
- Type:
- other: abiotic
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 3.9 d
- Type:
- other: abiotic
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 6.8 d
- Type:
- other: abiotic
- pH:
- 4
- Temp.:
- 35 °C
- DT50:
- 1.3 d
- Type:
- other: abiotic
- pH:
- 7
- Temp.:
- 35 °C
- DT50:
- 0.8 d
- Type:
- other: abiotic
- pH:
- 9
- Temp.:
- 35 °C
- DT50:
- 1.4 d
- Type:
- other: abiotic
- Conclusions:
- The half-lives in 20C water were 7.3, 3.9 and 6.8 days at pH 4, 7 and 9, respectively.
Reference
Breakdown products are not discussed in the report. However, it is known that hydrolysis of epichlorohydrin results in the formation of 3-Chloro-1,2-propanediol also known as alpha-monochlorohydrin.
Description of key information
Epichlorohydrin is susceptible to hydrolysis which will likely lead to 3-chloro-1,2,propanediol with a pseudo first order reaction half-life of 4 days at pH 7 and 20°C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4 d
- at the temperature of:
- 20 °C
Additional information
Epichlorohydrin is susceptible to hydrolysis which will likely lead to 3-chloro-1,2,propanediol, however no analytical work on the breakdown product was presented in the report. The half-life for this reaction has been determined in an OECD 111 study at three different pH values with half-lives ranging from 4 to 7 days at 20 °C. Similar half-lives were reported in another study (2.5–3.3 days). The half-life at neutral pH is anticipated to be lower compared to alkaline or acidic conditions, the first study cited reports slightly shorter half-lives at pH=7.
Epichlorohydrin will also react with other nucleophiles commonly present in waste water or natural waters (Thiols, Phenols, Alcohols).
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