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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin and eye irritation studies were conducted.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Doses of 0.1 -0.2 ml applied to the skin for 2 hours was necrotic with healing noted histopathologically. Higher doses for 24 hours resulted in a more severe response.

In the rabbit eye, 0.001 ml produced severe necrosis, while an excess of a 0.1% solution in water caused necrosis but a 0.01% solution did not.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly corrosive

Justification for classification or non-classification

In the rabbit eye, 0.001 ml produced severe necrosis. The material is thus classified as severly irritating.