Registration Dossier

Administrative data

Description of key information

Skin and eye irritation studies were conducted.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Doses of 0.1 -0.2 ml applied to the skin for 2 hours was necrotic with healing noted histopathologically. Higher doses for 24 hours resulted in a more severe response.

In the rabbit eye, 0.001 ml produced severe necrosis, while an excess of a 0.1% solution in water caused necrosis but a 0.01% solution did not.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly corrosive

Justification for classification or non-classification

In the rabbit eye, 0.001 ml produced severe necrosis. The material is thus classified as severly irritating.