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Physical & Chemical properties

Dissociation constant

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Description of key information

waiver, see Discussion

Key value for chemical safety assessment

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In accordance with Column 2 of Annex IX, the study does not need to be conducted if it is scientifically not possible to perform the test. In the case of epichlorohydrin (as well as other epoxides), the pKa for protonation of the epoxy ether atom is approximately -2 (as cited in "Brown WH, Foote CS, Iverson BL, Anslyn E (2009).Organic Chemistry, 5th Edition. 11: Ethers, Sulfids, and Epoxides. Brooks/Cole Publishers,,,), and thus cannot be measured under dilute aqueous solution conditions (pH ranging from 0-14), and is not relevant to pH encountered under environmental or physiological conditions