Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Epichlorohydrin has been reported to be positive in the following in vitro assays: Ames test without metabolic activation, in rat hepatocytes (UDS) and mouse lymphoma cells (HGPRT) and in the following in vivo assay in Drosophila (SRL). In other tests, including Drosophila (SRL), mouse dominant lethal assay and human lymphocyte DNA adduct assay, the results were negative with epichlorohydrin.


Short description of key information:
Epichlorohydrin has been reported to be positive in a number of in vitro and in vivo mutagenicity assays.

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

Because epichlorohydrin has not shown evidence of germ cell mutagenicity, no classification was considered.