Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

All test were conducted scientifically acceptable but the score values were not mentioned in the publication of the test results.

All tests with thymol were negative in the open epicutaneous test (OET), the Draize test (DT), the Maximisation test (MT) and the test with Freund's complete adjuvant (FCAT).

From a weight of evidence consideration thymol is not sensitizing.

Also from several patch test in humans conducted in dermatological institutions the sensitizing potential of thymol is very low


Migrated from Short description of key information:
An open epicutaneous test (OET), a Draize test (DT), a Maximisation test (MT) and a test with Freund's complete adjuvant (FCAT) were used for the detection of skin irritation and contact hypersensivity induced in guinea pigs

Respiratory sensitisation

Endpoint conclusion
Additional information:

no data


Migrated from Short description of key information:
no data

Justification for classification or non-classification

Based on the skin sensitzing test in animals and humans a classification is not justified