Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: according OECD 404

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report Date:
1986

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
content: Thymol 99.5 %

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
white New Zealand rabbits, weight 3 - 3.4 kg

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
not required
Amount / concentration applied:
amount: 500 mg
Duration of treatment / exposure:
4 hour(s)
Observation period:
14 days
Number of animals:
6 (3 males + 3 females)
Details on study design:
scoring according Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
2.1
Max. score:
4
Reversibility:
not fully reversible within: 14 d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
2.1
Max. score:
4
Reversibility:
not fully reversible within: 14 d
Other effects:
no data

Any other information on results incl. tables

corrosive in 6 of 6 animals

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

method: according OECD TG 404, 500 mg of the test substance were applied for 4 h on the skin of rabbits. Post observation time was 14 days

result: Thymol was classified as corrosive. The findings were not reversible within 14 days

reference: Ruf (Bayer AG), 1986