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EC number: 201-944-8 | CAS number: 89-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Study was conducted to determine the effect of test chemical on the larvicidal activity of Ochlerotatus caspius.
- GLP compliance:
- not specified
- Application method:
- contact
- Specific details on test material used for the study:
- - Name of test material (IUPAC Name): 2-Isopropyl-5-methylphenol- Common name: Thymol- Molecular formula: C10H14O- Molecular weight: 150.2196 g/mol- Smiles notation: c1(c(cc(C)cc1)O)C(C)C- InChI: 1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3- Substance type: Organic- Physical state: Solid- Chemical purchase from Sigma-Aldrich Co
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- DMSO
- Details on preparation and application of test substrate:
- Details on test solutionsPREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Chemical name of vehicle (organic solvent, emulsifier or dispersant): DMSO- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 1 ML
- Test organisms (species):
- other: Ochlerotatus caspius
- Animal group:
- Diptera (mosquitoe)
- Details on test organisms:
- - Laboratory culture: Larvae collected from salty rocky pools, from the shore of Enfe, Batroun Co., Lebanon
- Study type:
- laboratory study
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 24 and 48hrs
- Test temperature:
- 26°C
- Details on test conditions:
- Details on test conditionsTEST SYSTEM- Test vessel: Larval trays- Material, size, headspace, fill volume: Larval trays (9-3/4 × 7-3/4 in)- No. of organisms per vessel: 15- No. of vessels per concentration (replicates): 3- No. of vessels per control (replicates): 3- No. of vessels per vehicle control (replicates): 3OTHER TEST CONDITIONS- Photoperiod: 12 hours light and 12 hours darkEFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality were observed in the interval of 24 hrs.
- Nominal and measured concentrations:
- Testes at 4 different concentrations (5-30 ul/200 ml sea water)
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 33.31 other: mg/l
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95 % CI was 27.51 – 37.56 mg/l
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 33.65 other: Mg/l
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95 % CI was 27.83 – 38.37 mg/l
- Duration:
- 48 h
- Dose descriptor:
- other: LC90
- Effect conc.:
- 47.91 other: mg/l
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95 % CI was 42.96-57.61 mg/l
- Duration:
- 24 h
- Dose descriptor:
- other: LC90
- Effect conc.:
- 50.85 other: mg/l
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95 % CI was 45.18-61.38 mg/l
- Details on results:
- Larvae were consider dead if they did not move when they were slightly stimulated with a wooden stick.
- Reported statistics and error estimates:
- The lethal concentrations for 50% and 90% of the mortality were calculated using the Probit SPSS Analysis.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Test conducted for 48 hrs for determining the effect of chemical on the larvicidal activity of Ochlerotatus caspius (Mosquito). Based on the mortality of test organism for 48 hrs and 24hrs, the LC50 was determine to be 33.31 and 33.65 mg/l. and the LC90 was determine at 47.91 mg/l at 48 hrs and 50.85 mg/l after 24 hrs.
- Executive summary:
Study was conducted to determine the effect of test chemical on the larvicidal activity ofOchlerotatus caspius. Chemical was analytically monitorized by GC. 1 ml DMSO use as a solvent in which 200 ml sea water were added. Testes at 4 different concentrations (5-30 ul/200 ml sea water). Larvae collected from salty rocky pools, from the shore of Enfe, Batroun Co., Lebanon.Mortality were observed in the interval of 24 hrs. In which 3 replicates were used and in each larval tray 15 test organism added. Test conducted for 48 hrs for determining the effect of chemical on the larvicidal activity of Ochlerotatus caspius (Mosquito). Based on the mortality of test organism for 48 hrs and 24hrs, the LC50 was determine to be 33.31 and 33.65 mg/l. and the LC90 was determine at 47.91 mg/l at 48 hrs and 50.85 mg/l after 24 hrs.
Reference
Description of key information
Study was conducted to determine the effect of test chemical on the larvicidal activity of Ochlerotatus caspius. Chemical was analytically monitorized by GC. 1 ml DMSO use as a solvent in which 200 ml sea water were added. Testes at 4 different concentrations (5-30 ul/200 ml sea water). Larvae collected from salty rocky pools, from the shore of Enfe, Batroun Co., Lebanon.Mortality were observed in the interval of 24 hrs. In which 3 replicates were used and in each larval tray 15 test organism added. Test conducted for 48 hrs for determining the effect of chemical on the larvicidal activity of Ochlerotatus caspius (Mosquito). Based on the mortality of test organism for 48 hrs and 24hrs, the LC50 was determine to be 33.31 and 33.65 mg/l. and the LC90 was determine at 47.91 mg/l at 48 hrs and 50.85 mg/l after 24 hrs.
Key value for chemical safety assessment
Additional information
Toxicity to terrestrial arthropods:
Summarized result for the toxicity of chemical on the growth of terrestrial arthropods are as follows:
In the first key study for target chemical from peer reviewed journal toxicity was measured. Study was conducted to determine the effect of test chemical on the larvicidal activity of Ochlerotatus caspius. Chemical was analytically monitored by GC. 1 ml DMSO use as a solvent in which 200 ml sea water were added. Testes at 4 different concentrations (5-30 ul/200 ml sea water). Larvae collected from salty rocky pools, from the shore of Enfe, Batroun Co., Lebanon. Mortality were observed in the interval of 24 hrs. In which 3 replicates were used and in each larval tray 15 test organism added. Test conducted for 48 hrs for determining the effect of chemical on the larvicidal activity of Ochlerotatus caspius (Mosquito). Based on the mortality of test organism for 48 hrs and 24hrs, the LC50 was determine to be 33.31 and 33.65 mg/l. and the LC90 was determine at 47.91 mg/l at 48 hrs and 50.85 mg/l after 24 hrs.
Similarly the second study was also supports the nature of chemical from secondary source 2018. Study was conducted to determine the toxicity of chemical on Aedes aegypti. Test performed for 24 hrs on the 3-4 ins larval Aedes aegypti (Yellow Fever Mosquito). Based on the mortality of test organism Aedes aegypti (Yellow Fever Mosquito), by the chemical Thymol (5-Methyl-2-(1-methylethyl)phenol) exposure for 24 hrs, the LC50 was determine to be 79 mg/l. As the chemical was readily biodegradable in water thus consider as nontoxic and not classified as per the CLP classification criteria.
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