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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented for evaluation

Data source

Reference
Reference Type:
publication
Title:
Food flavourings and compounds of related structure I. Acute oral toxicity
Author:
Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG
Year:
1964
Bibliographic source:
Fd. Cosmet. Toxicol. 2, 327-343

Materials and methods

Principles of method if other than guideline:
Groups of 10 young adult Osborne-Mendel rats evenly divided by sex were fastened for approximately 18 hr prior treatment. Animals had access to water at all times, and the food was replaced in cages as soon as animals received their respective doses. All doses were given by intubation. All animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks. LD50's were computed by the method of Lichtfeld & Wilcoxon (1949), J.Pharmacol. 96, p.99
GLP compliance:
no
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Thymol (no data on purity)

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
propylene glycol
Doses:
no data
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
980 mg/kg bw

Any other information on results incl. tables

Toxic signs: Depression, ataxia, coma on high doses
Death time: 4 hr-5 days

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Executive summary:

method: 10 male and female rats received thymol as a 20% solution in propylene glycol per gavage.

result: LD50 = 980 mg/kg bw