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EC number: 201-944-8 | CAS number: 89-83-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of test chemical
- Author:
- COSMETIC INGREDIENT REVIEW
- Year:
- 2 006
- Bibliographic source:
- International Journal of Toxicology
- Reference Type:
- other: authoritative database
- Title:
- Acute toxicity - test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS database
- Reference Type:
- other: authoritative database
- Title:
- Acute toxicity : Test Chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 015
- Bibliographic source:
- HSDB
- Reference Type:
- secondary source
- Title:
- Test substance used to determine acute toxicity
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- TOXNET
- Reference Type:
- secondary source
- Title:
- Conclusion on the peer review of the pesticide risk assessment of the active substance
- Author:
- EFSA
- Year:
- 2 012
- Bibliographic source:
- EFSA Journal
- Reference Type:
- secondary source
- Title:
- Test chemical: Reregistration Eligibility Decision (RED)
- Author:
- U. S. Environmental Protection Agency (EPA)
- Year:
- 1 993
- Bibliographic source:
- U. S. Environmental Protection Agency (EPA)
- Reference Type:
- secondary source
- Title:
- DAR - test chemical
- Author:
- European Food Safety Agency (EFSA)
- Year:
- 2 011
- Bibliographic source:
- European Food Safety Agency
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity of Thymol (CAS no: 89-83-8) in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Thymol
- EC Number:
- 201-944-8
- EC Name:
- Thymol
- Cas Number:
- 89-83-8
- Molecular formula:
- C10H14O
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)phenol
- Details on test material:
- - IUPAC Name: Thymol- InChI: 1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3- Smiles: c1(c(cc(C)cc1)O)C(C)C- Molecular formula :C10H14O- Molecular weight :150.2196 g/mol- Substance type:Organic- Physical state:Solid, white crystalline powder, thyme-like, aromatic odor
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: Thymol- InChI: 1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3- Smiles: c1(c(cc(C)cc1)O)C(C)C- Molecular formula :C10H14O- Molecular weight :150.2196 g/mol- Substance type:Organic- Physical state:Solid, white crystalline powder, thyme-like, aromatic odor
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand rabbits
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: weighing 1.9 to 2.4 kg
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE - Area of exposure: clipped abraded abdominal skin
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days - Frequency of observations and weighing: Observations were made for mortality and toxic effects for 7 days, which was followed by gross necropsy.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 2000 mg/kg bw
- Clinical signs:
- other: At 24 h, rabbits had moderate erythema (10 of 10 rabbits), moderate edema (8 of 10 rabbits), or slight edema (2 of 10 rabbits). On day 7, moderate erythema was observed in 3 of 10 animals and slight erythema was noted in 4 of 10 animals.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal LD50 value was considered to be >2000 mg/kg bw, when 10 male and female New Zealand rabbits were treated with Thymol (CAS no: 89-83-8) by dermal application to the clipped abraded abdominal skin.
- Executive summary:
Acute dermal toxicity study of Thymol (CAS no: 89-83-8) was conducted in 10 male and female New Zealand rabbits at the dose concentration of 2000 mg/kg bw, to the clipped abraded abdominal skin.Observations were made for mortality and toxic effects for 7 days, which was followed by gross necropsy.No mortality was observed at 2000 mg/kg bw. At 24 h, rabbits had moderate erythema (10 of 10 rabbits), moderate edema (8 of 10 rabbits), or slight edema (2 of 10 rabbits). On day 7, moderate erythema was observed in 3 of 10 animals and slight erythema was noted in 4 of 10 animals. Hence LD50 value wasconsidered to be >2000 mg/kg bw, when10 male and female New Zealand rabbits were treated with Thymol (CAS no: 89-83-8) by dermal application to the clipped abraded abdominal skin.
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