Registration Dossier

Administrative data

Description of key information

A valid study according OECD 404 for skin irritation is available. As a result thymol is corrosive to the skin
Also a valid study for eye irritation according OECD 405 is available. In these study thymol was irritating to the eye

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

in the key study(skin irritation) thymol was corrosive

the mean value of the edema score (24, 48, 72 h) = 2.1

the mean value of the erythema (24, 48, 72 h) = 2.1

The findings were not reversible within 14 days

in the key study (eye irritation) of thymol

the mean value of the conjunctiva score (24, 48, 72 h) = 2.3 (mean value animal 1 -3)

the mean value of the cornea score (24, 48, 72 h) = 2 (mean value animal 1 -3)

the mean value of the iris score (24, 48, 72 h) = 1 (mean value animal 1 -3)

the mean value of the chemosis score (24, 48, 72 h) = 2.1 (mean value animal 1 -3)


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the result of the skin irritation/corrosion study a classification as C, R34 (GHS: Cat 1 B, H314) is justified.

Eye irritation is covered by the classification as corrosive