Registration Dossier

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Appearance:

Chemical thymol physically appear as a white crystalline powder having aromatic-thyme odor.

Melting point:

Melting point of chemical thymol is determine to be 49.5 Deg C.

Boiling Point:

Boiling point of chemical thymol is determine to be 232.5 Deg C.

Density:

Density of chemical thymol is determine to be 0.970 g/cm3 at temperature 25 Deg C.

Particle size distribution:

The particle size distribution of thymol was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 25 micron.

Vapour pressure:

Vapour pressure of chemical thymol is determine to be 133.2 Pa at temperature 64 Deg C.

Partition coefficient:

Based on the available data from peer reviewed journal, review article, secondary source, authoritative and modelling databases, the octanol water partition coefficient (log Pow) value of the test substance 2-Isopropyl-5-methylphenol was determined to be 3.3. On the basis of this experimental value, chemical 2-Isopropyl-5-methylphenol can be considered to be hydrophilic in nature.

Water solubility:

Water solubility of chemcial thymol is determine to be 900 mg/L at temperature 20 Deg C which indicates that thymol is moderately soluble in water.

Surface tension:

In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. Thymol (CAS no. 89-83-8)  is used as a Pharmaceuticals intermediates. For this use, surface activity is not an important property. Hence this study was considered for waiver.

Flash point:

Flash point of chemical thymol is determine to be 102 Deg C.

Auto flammability:

Thymol did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that thymol is not auto-flammable.

Flammability:

Thymol does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that thymol is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus thymol was considered non-flammable.

Explosiveness:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties.

Oxidizing properties:

The study does not need to be conducted because the substance is a solid

Additional information

Appearance:

Chemical thymol physically appear as a white crystalline powder having aromatic-thyme odor.

From other reliable sources & authoritative databases it is concluded that thymol appear as colorless crystals having herbal medicinal odor & white crystalline powder having pungent odor.

Melting point:

Melting point of chemical thymol is determine to be 49.5 Deg C.

From other reliable sources & authoritative databases it is concluded that melting point of thymol is in the range between 46.81 to 51.2 Deg C which is near to the key value.

Boiling Point:

Boiling point of chemical thymol is determine to be 232.5 Deg C.

From other reliable sources & authoritative database boiling point of chemical thymol is concluded in the range between 232 to 236.65 Deg C which is near to the key value.

Density:

Density of chemical thymol is determine to be 0.970 g/cm3 at temperature 25 Deg C.

From other reliable sources & authoritative databases density of thymol is concluded in the range between 0.9688 to 0.972 g/cm3 at various temperature conditions which is near to key value.

Particle size distribution:

The particle size distribution of thymol was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 25 micron.

Vapour pressure:

Vapour pressure of chemical thymol is determine to be 133.2 Pa at temperature 64 Deg C.

From other reliable sources & authoritative databases it is concluded that vapour pressure of thymol is concluded to be 100 Pa at temperature 59.5 Deg C, 2.1-2.2 Pa at temperature 25 Deg C, 2.133 Pa at temperature 25 Deg C & 0.2933 Pa at temperature 25 Deg C at various temperature conditions.

Partition coefficient:

Based on the available data in a key study from peer reviewed journal, review article, secondary source, authoritative and modelling databases, the octanol water partition coefficient (log Pow) value of the test substance 2-Isopropyl-5-methylphenol was determined to be 3.3.

Additional studyfromauthoritative databaseindicates that the octanol waterpartition coefficient (log Pow) value of the substance 2-Isopropyl-5-methylphenol was determined to be 3.14 at 25°C.

Thus, based on the available information, the logPow valueof the test substance 2-Isopropyl-5-methylphenol ranges from 3.14 to 3.3, respectively. On the basis of this experimental value, chemical 2-Isopropyl-5-methylphenol can be considered to behydrophilic in nature. 

Water solubility:

Water solubility of chemcial thymol is determine to be 900 mg/L at temperature 20 Deg C which indicates that thymol is moderately soluble in water.

From other reliable sources & authoritative databases it is concluded that water solubility of thymol is 980 mg/L at temperature 25 Deg C & 1000 mg/L which indicates that chemical is moderately soluble in water.

Surface tension:

In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. Thymol (CAS no. 89-83-8)  is used as a Pharmaceuticals intermediates. For this use, surface activity is not an important property. Hence this study was considered for waiver.

Flash point:

Flash point of chemical thymol is determine to be 102 Deg C.

From other reliable sources & authorative databases it is concluded that flash point of thymol is in between 102 to 110 Deg C.

Auto flammability:

Thymol did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that thymol is not auto-flammable.

Flammability:

Thymol does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that thymol is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus thymol was considered non-flammable.

Explosiveness:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties.

Oxidizing properties:

The study does not need to be conducted because the substance is a solid