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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: only abstract available, original literature in Japanese

Data source

Reference
Reference Type:
publication
Title:
Effects of phenolic dental medications on arachidonic acid metabolism and their anti-inflammatory action
Author:
Anamura S
Year:
1989
Bibliographic source:
Hiroshima Daigaku Shigaku Zasshi 21, 147-162

Materials and methods

Principles of method if other than guideline:
anti-inflammatory effect of thymol
GLP compliance:
no
Type of method:
other: in-vivo and in-vitro
Endpoint addressed:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: Thymol (no data on purity)

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Details on results:
The phenolic dental medications thymol etc. had anti-inflammatory effect against croton oil-induced ear edema in mice

Any other information on results incl. tables

In vitro studies in rabbit and bovine kidney medulla and tooth pulp microsomes and homogenates, rat tooth pulp homogenates, and human leucocytes indicated that the phenols inhibit PG and leucotriene biosynthesis in arachidonic acid metabolites, which may be the mechanism of their anit-inflammatory actions.

Applicant's summary and conclusion

Executive summary:

The phenolic dental medications thymol etc. had anti-inflammatory effect against croton oil-induced ear edema in mice.

In vitro studies in rabbit and bovine kidney medulla and tooth pulp microsomes and homogenates, rat tooth pulp homogenates, and human leucocytes indicated that the phenols inhibit PG and leucotriene biosynthesis in arachidonic acid metabolites, which may be the mechanism of their anit-inflammatory actions.