Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Male and female ICR mice were dosed by oral
gavage with 0, 500, 1000, or 2000 mg/kg BPA. Bone marrow cells were
collected at 24 or 48 hours after treatment and were examined
microscopically for the presence of micronucleated polychromatic
erythrocytes. No mortality occurred at any dose level during the course
of the study. Lethargy was noted in 2 of 5 male mice and 1 of 5 female
mice at 500 mg/kg and in all mice at 1000 and 2000 mg/kg. Piloerection
was observed in all mice at 1000 and 2000 mg/kg. Reductions of 15 to 24%
in the ratio of polychromatic erythrocytes to total erythrocytes were
observed in male and female dose groups 24 hours after treatment with
all doses of BPA. Reductions of 26% and 36% were observed in male and
female mice, respectively, 48 hours after treatment with 2000 mg/kg BPA.
The number of micronucleated polychromatic erythrocytes per 2000
polychromatic erythrocytes in BPA-treated groups was not increased
reltive to their respective vehicle controls in either males or females,
regardless of dose level or bone marrow collection time (p>0.05).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again