Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
There are no studies conducted
with validated methods to assess whether there is an association between Bisphenol
A exposure and
EFSA Opinion 2015 Conclusions on
"Based on recent human studies,
there are indications that Bisphenol A may be linked to immunological
outcomes in humans, although these studies had limitations and
confounding factors may have been present. A causal link between Bisphenol
A exposure during pregnancy or in childhood and immune effects in humans
cannot be established.
Studies in animals lend support
to the possibility of immunological effects of Bisphenol A. Most of
these studies suffered from shortcomings in experimental design and
reporting. Although dose-responses could not be confidently established
in most studies, a dose-related effect was observed in allergic lung
Using a WoE approach, the CEF
Panel assigned a likelihood level of “-as likely as not- to likely” to
immunotoxic effects of Bisphenol A. Since the likelihood level for this
endpoint is less than “likely” (see Appendix A), this endpoint was not
taken forward for assessing the toxicological reference point, but was
taken into account in the evaluation of uncertainty for hazard
characterisation and risk characterisation."
Bisphenol A is included in Annex
VI of Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again