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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
No macroscopic effects such as activity,
feeding, or locomotion differences were observed in polecats in any of
the treatment groups. Body weight was unaffected by BPA exposure when
comparing across treatment group and sex, but male polecats were found
to have a mean body mass almost twice that of females. For this reason
the BMI of males was significantly greater than the BMI of females
although there was no significant difference between BMIs of different
treatment groups. Absolute and relative liver weights were unaffected by
BPA exposure in both males and females with the exception of females in
the 250 mg/kg body weight/day group, whose mean and relative liver
weight were greater than those in the control group. Testosterone,
estradiol, and FSH concentrations were not significantly affected by BPA
exposure. T3, T4, and TSH levels were not significantly different with
respect to treatment group, although females were found to have
significantly higher T3/T4 ratios than males. Cortisol concentrations in
females were significantly decreased in the 50 mg BPA/kg body weight/day
group compared to females in the control. Plasma leptin concentrations
did not vary significantly between control and treatment groups. EROD
activity was not significantly affected by BPA exposure. GST levels
increased significantly in females exposed to 250 mg BPA/kg body
weight/day compared to female controls. UDPGT activity was significantly
increased in both males (250 mg/kg bw/day) and females (50 and 250 mg/kg
bw/day) compared to the control, when exposed to BPA. There was a
significant correlation between both UDPGT and GST levels, and BPA dose.
Discriminant analysis indicated an overall deviation from the physiology
of the control group when polecats were given BPA doses of 50 and 250
mg/kg bw/day with slight changes beginning somewhere between 10 and 50
mg/kg bw/day. The endocrine effects were less pronounced than the change
in enzyme activities. BPA induced phase II enzyme reactions (UDPGT and
GST) in a dose-dependent manner.
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