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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
There are four key studies which report of acute toxicity to fish for
fresh or marine water. The lowest LC50 value in each compartment was
used in the risk assessment to provide a conservative assessment.
Alexander et al., 1985, published in Alexander et al., 1988, determined
an LC50 of 4.6 mg/L in an OECD 203 study with Pimephales promelas (fresh
water). Springborn Bionomics, 1985a (published in Alexander et al.,
1988) reported an LC50 of 9.4 mg/L in an OECD 203 study with Menidia
menidia (marine water).
There are four key studies that are reliable without restriction which
characterise the acute toxicity of Bisphenol A towards freshwater and
marine water fish. All studies report of LC50 which refer to mortality.
The 96-hour flow-through exposure to the freshwater fish fathead minnow
(Pimephales promelas) in an OECD 203 study resulted in an LC50 of 4.6
mg/L (Alexander et al., 1985; published as Alexander et al., 1988). In
an extended acute toxicity (OECD 204) semi-static, 14-day study with
zebra fish (Danio rerio) a NOEC of 3.2 mg/ L was determined (Bayer AG,
The following two marine fish were tested in acute exposures. A 96-hour
acute flow-through exposure to the sheepshead minnow (Cyprinodon
variegatus) resulted in an LC50 of 11 mg/L in an OECD 203 study (Sayers,
2009). Similarly, a 96-hour acute flow-through exposure to the marine
fish Atlantic silverside (Menidia menidia) in an OECD 203 study,
resulted in an LC50 of 9.4 mg/L (Springborn Bionomics, 1985a; also
reported in Alexander et al., 1988).
Further supporting studies (all Klimisch 2) were identified which report
of LC50 in the range of 3.0 to 9.9 mg/L BPA. These were by Emmittee et
al., (1978) in a non-guideline study with Cyprinodon variegatus and a
96-h LC50 = 7.5 mg/L, Reif and Phil (1979) in an OECD 203 study with
Onchorhynchus mykiss and a 96-h LC50 = 3-5 mg/L, and Bayer (1989) with
Danio rerio and an 96-h LC50 = 9.9 mg/L.
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