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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
A single oral dose of 5000 mg/kg BPA was
administered by gavage to 5 male and 5 female Sprague Dawley rats after
an overnight fast. At the request of the study sponsor, a second group
of 10 animals (5 males, 5 females) was treated with a single oral dose
of 2000 mg/kg. Animals were observed for overt signs of toxicity or
behavioural changes at 1 and 4 hours after treatment and subsequently
once daily for 14 days. Body weights were recorded on the day before
treatment (day -1), the day of treatment, days 7 and 14, and at death.
All animals were subjected to gross necropsy examination. At 5000 mg/kg
BPA, 1 male and 5 females died within 1-2 days after treatment. Major
signs of toxicity noted on the day of dosing were lethargy, prostration,
hunched posture, and piloerection. Three surviving animals were
prostrate on the morning of day 1 and were found dead at afternoon death
check approximately 30 hours after dosing. At 2000 mg/kg BPA, no animals died,
but all animals were lethargic or prostrate on the day of dosing.
Occasional signs of chromodacryorrhoea and salivation were noted on the
day of dosing and on day 1. All surviving animals from both dose groups showed
gains in body weight at study termination. Common findings at necropsy
of animals that died during the study were associated with the liver and
gastrointestinal tract. All animals necropsied at study termination were
unremarkable. The authors concluded that the acute oral median lethal
dose of BPA in the rat was in excess of 2000 mg/kg and was approximately
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