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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Groups of 10 male and 10 female Fischer 344
rats were exposed by inhalation to 0 or 170 mg/cubic meter Bisphenol A
(the highest attainable concentration) for 6 hours. The mass median
aerodynamic diameter (MMAD) for the Bisphenol A aerosol was 3.9 µm
(geometric standard deviation = 3.5). Body weights were obtained on the
first day after exposure and approximately twice per week during a
14-day post-exposure period. Necropsies of 5 males and 5 females from
each group were performed the day after exposure. All other rats were
submitted for a gross necropsy examination at the end of the 14-day
post-exposure period. There were no deaths during the exposure period or
14-day recovery period. Body weight gains of males exposed to Bisphenol
A were slightly decreased from control values on the day after exposure,
but were comparable to control values within 3 days following exposure.
Body weights of females were comparable to control values. Soiling of
the face and forelimb in males and females and soiling of the perineal
region in females was observed one day after exposure. Acute
inflammation of the external nares and ulceration of the incisive ducts
were observed one day after exposure, but these changes were reversible
within the 14-day recovery period. No evidence for systemic toxicity was
observed throughout the study.
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