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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Bisphenol A is of low acute toxicity by all routes of exposure relevant to human health. Oral LD50 values beyond 2,000 mg/kg are reported in rodents, and dermal LD50 values above 2,000 mg/kg are indicated in the rabbit. For inhalation, a 6-hour exposure to 170 mg/m3 (the highest attainable concentration) produced no death in rats; slight and transient slight nasal tract epithelial damage was observed.
The 2003 EU RAR concluded:
"No useful information is available on the effects of single
exposure to Bisphenol A in humans. Oral LD50 values beyond 2,000 mg/kg
are indicated in the rat and mouse, and dermal LD50 values above 2,000
mg/kg are indicated in the rabbit. Few details exist of the toxic signs
observed or of target organs. For inhalation, a 6-hour exposure to 170
mg/m3 (the highest attainable concentration) produced no
death in rats; slight and transient slight nasal tract epithelial damage
was observed. These data indicate that Bisphenol A is of low acute
toxicity by all routes of exposure relevant to human health."
There is no reliable and significant new information on the acute
toxicity of Bisphenol A in the updated 2008 EU RAR or elsewhere.
Justification for selection of acute toxicity – oral endpoint
Jones 1985 reported LD50 >2000; NTP reported 4100 mg/kg as the
Bisphenol A is included in Annex 1 of Regulation 67/548/EEC and
Annex VI of Regulation (EC) No 1272/2008.
No classification regarding acute toxicity is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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