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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Groups of 30 male and 30 female rats were
exposed to 0, 10, 50, or 150 mg/m3 aerosolised Bisphenol A via whole
body exposure under dynamic airflow conditions for 6 hours per day, 5
days per week, for 13 weeks. Animals were observed daily and weighed
weekly. Ten animals/sex/exposure group were necropsied on the day after
the last exposure, and 10 animals/sex/exposure group were necropsied 4
and 12 weeks after the last exposure. Blood samples were obtained at
each sacrifice for hematologic and clinical chemistry determinations.
Major organs were weighed and tissues were evaluated
histopathologically. Slight stress-related effects were observed at all
concentrations of Bisphenol A, but except for decreased body weight of
male rats at the highest dose, these effects disappeared relatively
quickly after cessation of exposure. Enlarged ceca observed in rats
necropsied the day after exposure to the two highest doses were not
apparent in rats sacrificed 12 weeks later. Examination of the
respiratory tract revealed slight epithelial hyperplasia and chronic
inflammation in the submucosa in the nasal cavity at the two highest
doses. Similar but less severe changes were observed in rats after 4
weeks of recovery but only in the highest dose group. The minor
morphological changes were fully reversible within 12 weeks following
exposure. In conclusion, exposure to Bisphenol A by inhalation did not
result in any lower respiratory tract effects at any concentration
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