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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Mean serum total (unconjugated and conjugated) d6-BPA Cmax of 1711 nM
(390 ng/ml) was observed at
Tmax of 1.1 ± 0.50 h. Unconjugated d6-BPA appeared in serum within 5–20
min of dosing with a mean Cmax of
6.5 nM (1.5 ng/ml) observed at Tmax of 1.3 ± 0.52 h. Detectable blood
levels of unconjugated or total d6-BPA
were observed at 48 h in some subjects at concentrations near the LOD
(0.001–0.002 ng/ml). The half-times
for terminal elimination of total d6-BPA and unconjugated d6-BPAwere
6.4±2.0 h and 6.2±2.6 h, respectively.
Recovery of total administered d6-BPA in urine was 84–109%. Most
subjects (10 of 14) excreted >90% as metabolites
within 24 h.
"Conclusions: Using more sensitive methods, our study expands the
findings of other human oral pharmacokinetic studies. Conjugation
reactions are rapid and nearly complete with unconjugated Bisphenol A
comprising less than 1% of the total d6-Bisphenol A in blood at all
times. Elimination of conjugates into urine largely occurs within 24 h."
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