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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Two studies are available which were rated with Klimisch 2 (reliable,
with restrictions) were used in a weight-of-evidence (WoE) approach to
derive PNEC STP. Fabig (1988) reported an 18 h-EC10 of > 320 mg/L
(highest test concentration) with Pseudomonas putida. This study is not
the same as an activated sludge respiration test according to OECD 209
but there is indication of no toxicity towards P. putida as a
Stone and Watkinson (1983) as well is not an OECD 209 study but
investigated biodegradation with an bacteria growth inhibition test with
Pseudomonas fluorescens. The IC50 was reported as 54.4 mg/L.
Both studies were used in a WoE approach. The REACH guidance document
R.10 specifies that studies with P. fluorescens are of limited relevance
for STP as this species uses glucose as substrate. However, a growth
inhibition test with P. putida may be used for PNEC STP derivation. The
study of Fabig (1988) was conducted in accordance with DIN 38412-8 while
the recent REACH guidance document R.10 asks for ISO-10712 (1996).
Despite the fact that it is not totally certain if the DIN translated
directly into the ISO the study is considered sufficiently reliable to
be used in a WoE approach. Thus, the EC10 > 320 mg/L was used for PNEC
derivation. This approach was also taken in the European Risk Assessment
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