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EC number: 201-245-8
CAS number: 80-05-7
Bisphenol A; BPA
Ashby and Odom (2004)
conducted immature rat uterotrophic assays according to OECD protocols
(Kanno et al., 2003a; Kanno et al., 2003b) and examined uterine growth
and gene expression in rats administered Bisphenol A orally over the
dose range of 2 µg/kg/day to 800 mg/kg/day. Expression of three
oestrogen-responsive uterine genes and two control genes was determined
using real-time PCR. Increases in gene expression were observed over the
uterotrophic dose range (approximately 200 to 800 mg/kg/day Bisphenol A)
but not over the dose range of 2 to 20 mg/kg/day, in which there was no
uterotrophic response and no increase in gene expression. Thus, the no
effect level for uterotrophic activity of Bisphenol A coincided with the
no transcriptional effect level for uterine gene expression.
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