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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Pouvoir irritant des principaux solvants chlores aliphatiques sur la peau et les muqueuses oculaires du lapin
Author:
DUPRAT-P; DELSAUT-L; GRADISKI-D
Year:
1976
Bibliographic source:
EUR-J-TOXICOL 9 171-177

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: other: Eye irritation test as described by Kay and Calandra
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Supplied by Merck
Purity 99.5 %
Density 1.466

Test animals / tissue source

Species:
rabbit

Test system

Controls:
not required
Amount / concentration applied:
0.1 mL instilled into one eye
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
three

Results and discussion

In vivo

Results
Irritation parameter:
other: Indice d'Irritation Occulaire Aiguë (I.I.O.A.)
Basis:
mean
Time point:
other: no data
Score:
1
Max. score:
1
Reversibility:
fully reversible within: 2 weeks
Remarks on result:
other: no data on scores, but only slight irritation was observed, fully reversible within a few days. Study used in a WOE approach

Any other information on results incl. tables

Result: Moderate conjunctivitis was noted. Epithelial
keratitis was observed at day 7, but resolved by day 14.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
1,1,1-trichloroethane was foudn to be slighly irritating to the eye of the rabbit.
Executive summary:

In an eye irritation study 0.1 mL of 1,1,1 -trichloroethane was instilled into one eye of each of 3 rabbits. The reaction to reatment and degree of irritation was assessed according to Kay and Calandra. 1,1,1-trichloroethane was found to be slighly irritating to the eye of the rabbit.

The original paper is written in french, but the results are also reported in peer reviewed document published by ATSDR (Agency for Toxic Substances and Disease Registry), US Department of health and Human Services.