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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment and conducted at a well respected institution (ICI Chemicals)

Data source

Reference
Reference Type:
publication
Title:
Acute Inhalation Toxicity of Some Halogenated and Non-halogenated Hydrocarbons
Author:
CLARK-DG; TINSTON-DJ
Year:
1982
Bibliographic source:
HUM-TOXICOL 1 239-247

Materials and methods

GLP compliance:
no
Test type:
other: EC50 for cardovascular effects

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Supplied by Imperial Chemical Industries PLC to commercial specification or AR grade laboratory chemicals.

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Remarks:
no results given
Duration of exposure:
ca. 5 min
Concentrations:
Various - not specified
Control animals:
no
Details on study design:
Animals observed for cardiac effects - no details of how measurements taken specified
Statistics:
The EC50 and 95% confidence intervals were calculated using the moving average technique of Thompson (1947)

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: EC50 (cardiac sensitisation)
Effect level:
ca. 0.7 other: vol % in air
Exp. duration:
5 min
Sex:
not specified
Dose descriptor:
other: EC 50 (CNS effects)
Effect level:
ca. 0.5 other: vol % in air
Exp. duration:
5 min
Clinical signs:
None reported
Other findings:
Specific details of cardiac sensitisation not given, but considered by author to be either ventricular tachycardia or ventricular fibrillation

Applicant's summary and conclusion

Conclusions:
1,1,1-trichloroethane was assessed as part of an investigation looking at the relationship between structure and activity for a number of halogenated and non-halogenated hydrocarbons.

Dogs were exposed for at least 5 minutes and observed for clinical signs and mortality. The number of dogs or concentrations is not specified. The EC50 for CNS effects in the dog was 0.5 vol % in air and for cardiac effects 0.7 % vol in air, following 5 minutes exposure.
Executive summary:

1,1,1-trichloroethane was assessed as part of an investigation looking at the relationship between structure and activity for a number of halogenated and non-halogenated hydrocarbons. 

Dogs were exposed for at least 5 minutes and observed for clinical signs and cardia effects.  The number of dogs or concentrations is not specified.  The EC50 for CNS effects in the dog was 0.5 vol % in air and for cardiac effects 0.7 % vol in air, following 5 minutes exposure.